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一年一度的2008年诺贝尔生理学或医学奖(生物奖)揭晓啦，每年过完国庆都会无比期待今年的诺贝尔生理学或医学奖花落谁家。 In 2008 the annual Nobel Prize in Physiology or Medicine (biological Prize) announced it each year over the National Day will be finished very looking forward to this year's Nobel Prize in Physiology or Medicine whose flowers. 诺贝尔生物学奖算是俺们生物专业学生最受关注的新闻吧。 An Men regarded as the Nobel Prize for biology students of biological information it the most talked about.

晚上已经在诺贝尔奖官方网站上看到了今年诺贝尔生物学奖得主 ，当时看的时候网站还没上传获奖得主头像。 Nobel Prize in the evening has been the official site of this year saw the biology of the Nobel Prize winner, then look at the site before uploading time winner of the award-winning portrait. 看来诺贝尔奖的评审及公布程序真的很严格，也许这些诺贝尔生物奖获得者图像是刚刚拍摄采集的呢。 Nobel Prize-winning appear to review and publication process is very strict, they may be the Nobel Prize-winning bio-image is shooting just collected it.

据诺贝尔奖官方网站消息，10月6日当地时间上午11时30分左右(北京时间17时30分左右)，瑞典皇家科学院诺贝尔奖委员会宣布将2008年度诺贝尔生理学或医学奖授予授予德国科学家楚尔郝森和两位法国科学家巴雷-西诺希和路克-蒙塔尼埃 。 According to the official website of the Nobel Prize, on October 6, local time 11:30 or so (Beijing time 17:30 or so), the Royal Swedish Academy of Sciences Nobel Committee announced the 2008 Nobel Prize in Physiology or Medicine awarded Germany Scientists Eitan Haosen Barre and the two French scientists - Xinuo Xi and Luke - Mengtaniai. 德国科学家因发现人乳头淋瘤病毒引发子宫颈癌获此殊荣，两名法国科学家因发现人类免疫缺陷病毒(HIV)获此殊荣。 German scientists have found that as a result of human papilloma virus nipple rain caused cervical cancer to be so honored, two French scientists found that as a result of human immunodeficiency virus (HIV) to be so honored.

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发育遗传学权威杂志Genes & Development (基因与发育)最新发表了一篇Hedgehog信号转导途径研究进展，简单翻译下。 Developmental Genetics journal Genes & Development (Genes and Development) recently published an article Hedgehog signal transduction research, under a simple translation. 该综述详细论述了Hedgehog信号通路产生机制及生物学功能，并探讨了Hedgehog信号通路在人类癌症治疗可能具有的潜在应用价值。 Summary of the detail of the Hedgehog signaling pathway and mechanism of biological functions, and to explore the Hedgehog signaling pathway in human cancer treatment may have potential application.

Hedgehog (Hh)蛋白家族调控细胞生长，细胞存活，细胞命运决定等脊椎动物几乎所有模式形成过程的各个方面。 Hedgehog (Hh) family of proteins control cell growth, cell survival, the fate of cells in almost all vertebrates, and so decided to form a pattern in all aspects of the process. 单独的一种形态发生子(morphogen)能产生这么广泛的影响是可能的，因为细胞对Hedgehog信号通路的响应依赖于不同细胞种类、接收到的Hedgehog信号剂量强度、以及相应Hedgehog信号的具体时间。 A separate sub-morphogenetic (morphogen) can produce such a wide-ranging impact is possible because cells on the Hedgehog signaling pathway depends on the response of different cell types, to receive the Hedgehog signal strength dose, as well as the Hedgehog signal corresponding to the specific time.

并且Hedgehog的信号梯度由加工、分泌、运输Hedgehog信号所需蛋白特化。 Hedgehog and the signal processing by the gradient, secretion, transport Hedgehog signaling protein required for specialization. 细胞响应机制又协同负反馈循环进一步微调Hedgehog信号。 Cell response and coordination mechanism for negative feedback loop to further fine-tuning Hedgehog signal. 影响到Hedgehog信号转导途径的生殖细胞突变体往往伴随发育过程紊乱，同时，激活Hedgehog信号转导通路的体细胞突变往往伴随多种人类癌症的发生。 Impact on the Hedgehog signal transduction of germ cell mutation is often accompanied by development disorder, at the same time, the activation of Hedgehog signaling pathway of cell mutation is often accompanied by a variety of human cancer.

这篇综述详细介绍了最新Hedgehog信号转导途径研究进展 ，阐述了Hedgehog信号转导通路的发生机制及发育生物学功能。 This overview of the latest details of Hedgehog signal transduction research on the Hedgehog signaling pathway and mechanism of developmental biology function. 另外，本综述也讨论了人类疾病发生的病理生物学过程，以探寻人类疾病的潜在治疗方法。 In addition, the Review was also discussed human Biology pathology of the disease process, in order to explore the potential of the human disease treatment.

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2008世界大学科研论文质量评比国内各地区排名。 2008 World University research paper rating the quality of the domestic regional rankings. 阅读全文» Read the full text »

在上一篇日志中简要介绍了一下台湾财团法人高等教育评鉴中心基金会去年针对世界大学科学研究论文进行质量表现评比，首度研发推出「世界大学科研论文质量评比」排名系统(HEEACT Ranking )，从「学术生产力」、「学术影响力」及「学术卓越性」三大评估面向，发布世界大学科研论文质量评比:2008世界科研论文排名 ，列出世界前五百大名单，以中英文分别公布于网站。 In an article on the log briefed about the Taiwan Foundation Center for Higher Education Accreditation Foundation for last year's World University scientific research papers for the quality of performance evaluation, research and development for the first time to launch the "World University research paper quality rating" system of ranking (HEEACT Ranking) From the "academic productivity" and "academic influence" and "academic excellence" for the three major assessment, published in the world rating the quality of university research papers: 2008 research paper in the world ranking, listing the world's top 500 list of largest, in both English and Chinese Were published on the website.

有些读者发信询问是否有英文原文或者什么PDF格式下载，看来大家对这个排名还是很感兴趣的。 Some readers asked whether the letter in English, or what the original PDF format to download, it seems that everyone is very interested in the position of. 很简单，今天到「世界大学科研论文质量评比」系统官方网站HEEACT ranking进行查询。 Very simple, "university in the world of scientific research papers quality rating" system, the official website of HEEACT ranking query.

ranking review in english ranking review in english

2008 Performance Ranking of Scientific Papers for World Universities 2008 Performance Ranking of Scientific Papers for World Universities

Methodology

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为了解台湾研究型大学的学术竞争力，台湾财团法人高等教育评鉴中心基金会去年首度研发推出「世界大学科研论文质量评比」排名系统(HEEACT Ranking )，从「学术生产力」、「学术影响力」及「学术卓越性」三大评估面向，针对世界大学科学研究论文进行质量表现评比，列出世界前五百大名单，以中英文分别公布于网站。 In order to understand the Taiwan Research at the University of academic competitiveness, the Taiwan Foundation Center for Higher Education Accreditation Foundation R & D for the first time last year launched the "World University research paper quality rating" system of ranking (HEEACT Ranking), "academic productivity" and "academic influence Force "and" academic excellence "for the three assessment, scientific research papers for the World University for the quality of performance appraisal, listing the world's top 500 list of largest, in both English and Chinese were published in the website. 其中台湾5校进前500大，大陆高校方面清华大学(152名),北京大学(164名),香港大学(173名)。 Taiwan 5, in which the former school into the 500 mainland colleges and universities regard of Tsinghua University (152), Beijing (164), the University of Hong Kong (173).

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奥运会已经结束，而与此同时，在2008年北京奥运会开幕之际，与《自然》、《科学》并列的国际顶尖杂志《细胞》刊登专题文章《中国科学三十周年》（Science in China: 30 years on）介绍中国的生命科学。 Olympic Games is over, but at the same time, in the 2008 Beijing Olympic Games opening ceremony, and "natural" and "Science" magazine's top international side by side "cells" published in the article, "the thirtieth anniversary of the Chinese Science" (Science in China: 30 years on) about China's life sciences. “从国家对于体育的财政投入来看，从1998年开始体育的投入不断增加，到2006年和2007年每年都将近90亿美元。这个数字是惊人的，从1998到现在每年都超过了国家对于基础科研的投入”。 "From a national sport for the financial investment, since 1998, growing into the sport, in 2006 and 2007, each year nearly 90 million. This figure is alarming, from 1998 to the present all over the country each year for On the basis of scientific input. " 一个国家的科研实力，决定了这个国家发展的最大源动力。 A country's scientific strength, determined the development of the country's largest power source. 我们金牌拿到了第一，怎样在科研领域拿到更多的“金牌”？ We got the first gold medal, how in the field of scientific research and more "gold"? 这也许是一个值得深思的问题。 This may be a thought-provoking questions. 但不管怎样，就纵向比较而言，在生物科学领域，近年来我国对其科研尤其是基础研究的资金投入正在逐年稳步增加。 In any case, on the vertical comparison, in the biological sciences, scientific research in China in recent years in particular, its basic research funding is steadily increasing year by year.

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蛋白质-蛋白质相互作用图谱能对细胞功能和蛋白组机制提供有用信息。 Protein - protein interaction map for the cells to proteome and the function of a mechanism to provide useful information. 除了在线预测蛋白相互作用外，通过比较具有相对专一性语义关系的的两基因语义注释(Gene Ontology terms, GO)的相似性，可以得到重建酵母蛋白互作网络图谱的新方法。 In addition to the on-line prediction protein interaction, through comparison with the relative specificity of the relationship between the semantic meaning of the two gene Notes (Gene Ontology terms, GO) similarity could be the reconstruction of yeast protein interaction map of the network's new approach. 为了验证这种方法的有效性，利用高置信蛋白互作标准数据校正确认。 In order to verify the validity of this approach, the use of high-confidence protein interaction standard calibration data to confirm.

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蛋白质-蛋白质间互相作用(Protein–protein interaction, PPI)信息提取与分析已成为文本提取( bio-text mining,也叫文本挖掘)重要领域，因为这些蛋白-蛋白间互作信息是理解生物过程的关键。 Protein - protein interaction between (Protein-protein interaction, PPI) information extraction and analysis of the text has been extracted (bio-text mining, text mining, also known as) important areas, such as protein - protein interaction between the information is to understand the biological processes Key. 目前网络上可利用的开放系统还很少，而且很多是基于单纯的关键词预测方法。 At present, the network can make use of the open systems is also very small and many of them are based on simple keywords forecasting.

下面简单推荐介绍一个蛋白质间相互作用在线预测的网站。 The following simple recommendation to introduce an online prediction of protein interaction site. 不仅可以直接输入文本内容，而且可以上传txt/html/pdf格式的整个文件(注意html/pdf格式论文会产生干扰噪值) ，值得一提的是可以和PubMed形成接口，如直接填入Session ID或PubMed Search 结果的ID。 Not only can enter text, and can upload txt / html / pdf format of the document as a whole (Note html / pdf format paper will have a value of the noise interference), it is worth mentioning that could PubMed interface formation, such as direct fill Session ID or PubMed Search the results of the ID.

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